Remicade®(For medical professional reference only)

<p><strong><u>Rheumatoid arthritis:</u></strong><br>REMICADE is a Disease Controlling Anti-Rheumatic Therapy (DCART); in combination with methotrexate, REMICADE is indicated for:</p><div>•reducing signs and symptoms,</div><div>•Improving physical function and preventing disability in patients</div><div>•in patients with moderately to severely active rheumatoid arthritis.&nbsp;</div><p><strong><u>Crohn’s disease</u></strong><br>REMICADE is indicated for:</p><div>•reducing signs and symptoms</div><div>•inducing and maintaining clinical remission</div><div>•inducing mucosal healing in adults</div><div>•improving quality of life</div><div>•Reducing or stopping the use of&nbsp; corticosteroids</div><p>in patients with moderately to severely active Crohn’s disease who have had an inadequate response to conventional therapy. REMICADE enables patients to reduce or eliminate corticosteroid use.<br><strong>Fistulizing Crohn’s disease</strong><br>REMICADE is indicated for:</p><div>•reducing the number of draining enterocutaneous and rectovaginal fistulas and maintaining fistula closure</div><div>•reducing signs and symptoms</div><div>•improving quality of life</div><div>•in patients with fistulizing Crohn’s disease.</div><p><strong>Ankylosing spondylitis:</strong></p><div>•REMICADE is indicated for:</div><div>•improving signs and symptoms, including range of motion</div><div>•improving physical function</div><div>•improving quality of life</div><div>•in patients with active ankylosing spondylitis.</div><p><strong>Psoriasis</strong><br>Remicade is indicated for treatment of adult patients with chronic severe plaque psoriasis who failed to respond to, or who have a contraindication to, or are intolerant to other systemic therapy including cyclosporine, methotrexate or PUVA. REMICADE should only be administered to patients who will be closely monitored and have regular follow-up visits with a physician.</p>